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Nondisjunction of sex chromosomes

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Nondisjunction is the failure of two members of a homologous pair of chromosomes to separate during meiosis. It gives rise to gametes with a chromosomal content that is different from the norm. The consequences of this are usually quite severe, and a number of clinical conditions are the result of this type of chromosome mutation. Homologous chromosomes are virtually identical chromosomes that occur in pairs, one member inherited from each parent.
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Disorders of the Sex Chromosomes - WikiLectures

Aneuploidy, an abnormal number of chromosomes in a cell, is caused by nondisjunction, or the failure of chromosomes to separate at meiosis. Of all of the chromosomal disorders, abnormalities in chromosome number are the most obviously identifiable from a karyotype and are referred to as aneuploidy. Aneuploidy is a condition in which one or more chromosomes are present in extra copies or are deficient in number, but not a complete set. To be more specific, the loss of a single chromosome from a diploid genome is called monosomy 2n They are caused by nondisjunction, which occurs when pairs of homologous chromosomes or sister chromatids fail to separate during meiosis. Misaligned or incomplete synapsis, or a dysfunction of the spindle apparatus that facilitates chromosome migration, can cause nondisjunction. The risk of nondisjunction occurring increases with the age of the parents.
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What is Nondisjunction and What are its Effects?

Trisomy 21 pp Cite as. Nondisjunction of the sex chromosomes in man. Estimates of the frequencies of nondisjunctional gametes of types XX, XY, YY, and 0 originating at first and second meiotic divisions in oogenesis and spermatogenesis are given in Tables 2 and 5.
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Human Chromosomal Disorders April 30, Karyotype preparation and analysis. Cells from blood, amniotic fluid, etc are grown in vitro in a cell culture dish to increase their number. Cell division is then arrested in metaphase with colchicine prevents mitotic spindle from forming.
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